Washington [US], June 11 (ANI): A new study shows that obese people are actually healthy (metabolic) because having a normal metabolic profile increases their risk of diabetes and heart disease. It is not always called healthy obesity). Stroke, and respiratory illness.
The results of this study were published in the journal “Diabetologia” of the European Diabetes Foundation (EASD).
The study was conducted by Dr. Frederick Ho and his colleagues at the Institute of Health and Welfare, University of Glasgow, Glasgow, UK. They investigated whether individuals who were obese and had a normal metabolic profile were healthy, or whether they were also at high risk of developing obesity-related health problems.
It is estimated that there are more than 300 million obese people in the world, and if the current trend continues, this figure could exceed 1 billion by 2030 and account for 20 percent of the world’s adult population. There is sex.
An ongoing global epidemic of type 2 diabetes (T2D), hypertension, cardiovascular disease (CVD), and many other serious health problems is associated with obesity.
Obesity usually causes metabolic problems characterized by elevated blood sugar levels, elevated blood pressure (BP), insulin resistance, and other adverse metabolic changes. These effects are not universal, and some obese people have healthy levels of insulin with normal blood pressure, favorable blood fat, and little or no systemic inflammation.
This is sometimes referred to as “metabolic healthy obesity” (MHO), and its incidence is estimated to be 3% to 22% of the total population.
This study examined the association between MHO and all-cause mortality, T2D, heart attack and stroke, heart failure (HF), and respiratory illness, including chronic obstructive pulmonary disease (COPD).
MHO is a body mass index (BMI) of 30 kg / m2 or higher and is defined as meeting at least 4 of the 6 metabolically healthy criteria. These include blood pressure and five blood-based biomarkers: C-reactive protein (CRP, marker of inflammation), triglyceride (fat), low-density lipoprotein (LDL / “bad” cholesterol) and high density. Lipoprotein (HDL /’good cholesterol), and glycated hemoglobin (HbA1c, measured mean blood glucose over the last 2-3 months).
Based on metabolic and obese status, participants participated in metabolically healthy non-obesity (MHN), metabolically healthy obesity (MHO), metabolically unhealthy non-obesity (MUN), and metabolically unhealthy. It was classified as obese (MUO).
The authors analyzed the details of 381,363 people (excluding those classified as “underweight”) for a median follow-up of 11.2 years. They were part of the UK Biobank project. A large prospective cohort study of participants from the general population of England, Scotland and Wales from 2007 to 2010.
The authors found that MHO individuals are generally younger, less watched on television, more active, more educated, have lower deprivation indices, consume more lean and processed meats, and are more than MUO participants. We have found that it is unlikely to be male or non-white.
Compared to non-obese, metabolically healthy participants (MHN), MHO participants are 4.3 times more likely to have type 2 diabetes, 18% more likely to have a heart attack or stroke, and are at risk of heart failure. Was 76% higher, 28%. You are more likely to have respiratory illness and are 19% more likely to have COPD.
People classified as MHO were 28% more likely to suffer from heart failure than those who were not obese and were metabolically unhealthy (MUN).
The authors found that “generally, the rate of cardiovascular and respiratory outcomes was highest in MUO, followed by MUN and MHO, but with accidental and fatal heart failure, and accidental respiratory illness. Excluded. For these outcomes, the MHO people are MUN. “They added. “Metabolic healthy obese people are at significantly higher risk of diabetes, heart attack and stroke, heart failure, respiratory illness, and death from all causes compared to people with a healthy metabolic profile rather than obesity. Of particular note is that metabolically healthy obese people are at higher risk of heart failure and respiratory illness than non-obese, metabolically unhealthy participants. ”In addition, the team follows. Among a subset of participants with up-metabolism and obesity data, one-third of people with metabolically healthy obesity at the beginning of the study period became metabolically unhealthy within 3-5 years. It was.
“Healthy people are” healthy “because they are at higher risk of heart attack, stroke, heart failure, and respiratory disease than non-obese people with a normal metabolic profile,” the researchers said. Not. ” Weight management can be beneficial for all obese people, regardless of their metabolic profile. The term “metabolically healthy obesity” is misleading and should be avoided in clinical medicine and considered various strategies for defining risk. (Ani)
People with “healthy obesity” are still at risk of illness
SourcePeople with “healthy obesity” are still at risk of illness