The “game substitute” drug for cancer can be used to treat patients with heart attack as scientists I hope they can prevent irreversible damage.
University of Bristol The researchers conducted tests on mice that showed that the drug, known as the MEK inhibitor, prevents long-term damage after a heart attack.
We hope the treatment can be applied to humans, and Professor Paolo Madedo, who is leading the study, describes the findings as “extremely cited”.
The MEK inhibitor is currently used to treat some types of melanoma and lung cancer and works by stimulating cells called pericytes that line the veins.
They then transform into completely different cell types, leading to the growth of new healthy blood vessels.
Mr Madedu said that ideally, the MEK inhibitor would be given to patients after they had had a heart attack.
“It could be a long-awaited game changer to treat a heart attack,” he said Დروება.
“If we can expand new blood vessels in the critical period after a heart attack, it will improve blood circulation to the heart and save cells.”
The British Heart Foundation Sponsored a study in which mice were treated with the drug for 14 days after a heart attack.
The researchers found that mice given the MEK inhibitor were more likely to survive than those given no.
Tests on human cells have shown that the drug successfully “alters the characteristics of pericytes” to stimulate the growth of endothelial cells that line blood vessels.
Scientists hope to begin clinical trials on humans in the next 12 months. They believe the drug could be approved quickly because it is already being used by the NHS to treat cancer.
The data show that about 100,000 people suffer a heart attack each year.
Professor Metin Avkiran, Associate Medical Director of the British Heart Foundation, said: “This is a significant step forward in our understanding of how new blood vessels can grow in hearts damaged by a heart attack.
“The more people who survive a heart attack, the more people live with a damaged heart and the risk of developing heart failure. Thousands of families in the UK are watching how they struggle with this devastating condition of loved ones.
He added: “New treatments that improve blood flow to surviving heart muscle, such as the MEK inhibitor studied here, may help maintain heart function and prevent progression to heart failure. Further research is needed to confirm the safety and efficacy of MEK inhibitors. In a clinical setting, but this study offers real hope for a new approach to preventing heart failure.
Heart medication can “change the game” and prevent irreversible damage
Source link Heart medication can “change the game” and prevent irreversible damage